Pharma Izithako
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I-Fmoc-Ls(Pal-Glu-OtBu)-OH
I-Fmoc-Lys(i-Pal-Glu-OtBu)-OH yibhloko ekhethekileyo ye-amino acid yokwakha eyenzelwe i-peptide-lipid conjugation. Ibonisa i-lysine ekhuselweyo ye-Fmoc kunye nekhonkco lecala le-palmitoyl-glutamate, ukuqinisa ubudlelwane be-membrane kunye ne-bioavailability.
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Fmoc-Yakhe-Aib-OH
I-Fmoc-His-Aib-OH yibhloko yokwakha yeepeptide esetyenziswa kwi-peptide synthesis, edibanisa i-Fmoc-protected histidine kunye ne-Aib (α-aminoisobutyric acid). I-Aib yazisa ukuqina kwe-conformational, iyenza ixabiseke ekuyileni i-helical kunye ne-stable peptides.
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Boc-His(Trt)-Aib-Glu(OtBu)-Gly-OH
I-Boc-His (Trt)-Aib-Glu (OtBu)-Gly-OH isiqwenga se-tetrapeptide ekhuselweyo esisetyenziswe kwi-peptide synthesis kunye nophuhliso lweziyobisi. Iqulethe amaqela asebenzayo akhuselweyo ngobuchule bokudibanisa i-stepwise kunye neempawu ze-Aib (α-aminoisobutyric acid) ukunyusa uzinzo lwe-helix kunye nobulukhuni be-conformational.
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Ste-γ-Glu-AEEA-AEEA-OSU
I-Ste-γ-Glu-AEEA-AEEA-OSU yi-synthetic lipidated linker molecule eyenzelwe ukuhanjiswa kwechiza ekujoliswe kulo kunye ne-antibody-drug conjugates (ADCs). Ibonisa umsila we-stearoyl (Ste) we-hydrophobic, i-γ-glutamyl ejoliswe kuyo, i-AEEA spacers yokuguquguquka, kunye neqela le-OSu (NHS ester) lokudibanisa ngokufanelekileyo.
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Fmoc-Ile-αMeLeu-Leu-OH
I-Fmoc-Ile-αMeLeu-Leu-OH yibhloko yokwakha ekhuselweyo ye-tripeptide ene-α-methylated leucine, esetyenziswa ngokuqhelekileyo kwi-peptide yoyilo lweziyobisi ukuphucula ukuzinza kwe-metabolic kunye nokukhetha kwe-receptor.
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I-Dodecyl Phosphocholine (DPC)
I-Dodecyl Phosphocholine (DPC) sisicoci sokwenziwa se-zwitterionic esisetyenziswa kakhulu kuphando lweprotheyini yenwebu kunye nebhayoloji yolwakhiwo, ngakumbi kwi-NMR spectroscopy kunye necrystallography.
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I-Donidalorsen
I-Donidalorsen API yi-oligonucleotide ye-antisense (ASO) ephantsi kophando lonyango lwe-angioedema ye-hereditary (HAE) kunye neemeko ezinxulumene nokuvuvukala. Kufundwa kumxholo wonyango olujoliswe kwi-RNA, ejolise ekunciphiseni ukubonakaliswa kweplasma prekallikrein(KLKB1 mRNA). Abaphandi basebenzisa i-Donidalorsen ukuphonononga iindlela zokuthulisa imfuza, i-pharmacokinetics exhomekeke kwidosi, kunye nolawulo lwexesha elide lokudumba kwe-bradykinin-mediated.
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IFitusiran
I-Fitusiran API yi-RNA encinci ephazamisayo (i-siRNA) ephandwe ngokukodwa kwintsimi ye-hemophilia kunye nokuphazamiseka kwe-coagulation. Ijolise kwii-antithrombin (AT okanye i-SERPINC1)gene esibindini ukunciphisa imveliso ye-antithrombin. Abaphandi basebenzisa i-Fitusiran ukuphonononga iindlela zokuphazamiseka kwe-RNA (i-RNAi), ukuthuliswa kofuzo oluthile lwesibindi, kunye nezicwangciso zonyango ezinoveli zokubuyisela i-coagulation kwi-hemophilia A kunye ne-B izigulane, kunye okanye ngaphandle kwe-inhibitors.
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Givosiran
I-Givosiran API yi-RNA encinci ephazamisayo (i-siRNA) efundela unyango lwe-acute hepatic porphyria (AHP). Ijolise ngokukodwa kwiI-ALAS1gene (i-aminolevulinic acid synthase 1), ebandakanyeka kwi-heme biosynthesis pathway. Abaphandi basebenzisa i-Givosiran ukuphanda ukungenelela kwe-RNA (RNAi)-based therapies, ukuthulisa i-gene ejoliswe kwisibindi, kunye nokuguqulwa kweendlela ze-metabolic ezibandakanyekayo kwi-porphyria kunye nokuphazamiseka kwemfuza okuhambelanayo.
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Plozasiran
I-Plozasiran API yi-RNA encinci ephazamisayo (i-siRNA) ephuhliselwe unyango lwe-hypertriglyceridemia kunye ne-cardiovascular and metabolic disorders. Ijolise kwiAPOC3gene, efaka i-apolipoprotein C-III, umlawuli oyintloko we-triglyceride metabolism. Kuphando, i-Plozasiran isetyenziselwa ukufunda izicwangciso ze-RNAi-based based lipid-downing, i-gene-sincing specificity, kunye nonyango oluthatha ixesha elide kwiimeko ezifana ne-familial chylomicronemia syndrome (FCS) kunye ne-dyslipidemia edibeneyo.
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Zilebesiran
I-Zilebesiran API yi-RNA encinci ephazamisayo yophando (i-siRNA) ephuhliselwe unyango lwe-hypertension. Ijolise kwiAGTgene, efaka i-angiotensinogen-inxalenye ephambili yenkqubo ye-renin-angiotensin-aldosterone (RAAS). Kuphando, i-Zilebesiran isetyenziselwa ukufunda iindlela zokuthulisa i-gene yokulawula uxinzelelo lwegazi ixesha elide, iteknoloji yokuhambisa i-RNAi, kunye nendima ebanzi yendlela ye-RAAS kwi-cardiovascular and renal disease.
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I-Caspofungin ye-Antifungal Infections
Igama: Caspofungin
Inombolo ye-CAS: 162808-62-0
Ifomula yemolekyuli: C52H88N10O15
Ubunzima bemolekyuli: 1093.31
Inombolo ye-EINECS: 1806241-263-5
Indawo yokubilisa: 1408.1±65.0 °C (Kuqikelelwe)
Ubuninzi: 1.36±0.1 g/cm3(Kuqikelelwe)
I-Acidity coefficient: (pKa) 9.86±0.26 (Kuqikelelwe)