Pregabalin kunyango lwe-neulgie ye-mealgia kunye nonyango olungeyomfuneko lokuphazamiseka kwendawo yokuhlala
Iinkcukacha zemveliso
| Igama | Pregabalin |
| Inombolo ye-CAS | I-148553-50-50 |
| Ifomula yemolekyuli | C8h17no2 |
| Ubunzima bemolekyuli | I-159.23 |
| Inombolo ye-einecs | 604-639-1 |
| Indawo yokubila | 274.0 ± 3.0 ° C |
| Ubunyulu | I-98% |
| Ukugcinwa | Itywinwe kubushushu bomileyo, igumbi |
| Ifom | Umgubo |
| Umbala | Mhlophe |
| Ukupakisha | Ibhegi ye-PE + i-aluminium Bag |
Izithethantonye
I-3 (s) - (i-amimoomethyl) -5-methylhexaxanoc acid; (3s) -3- (i-Aminomethyl)-(i-methythyl)-(i-methythylic acid; (R ) -Pregabhalin; (s) -pgetalin
Isiphumo se-Pharmacociological
Isiphumo se-Pharmacociological
I-Pregabalin inefuthe elilungileyo lonyango. Izifundo kwiimodeli zokuphelisa izilwanyana ezinesilwanyana zibonakalisile ukuba i-Pregabalin ingathintela ngokugqwesileyo i-feiiiighptic and thedoms i-3-10 amaxesha esezantsi kuneGabapentin. Izifundo ziye zafumanisa ukuba i-Pregalin ingayinciphisa iimvakalelo kunye ne-spinal ye-pinal ye-rat pinch-toe, inciphise indlela yokuziphatha enxulumene ne-neuropathic yezilwanyana ezinesifo sefonti ye-neuropathic, i-chemotheraple ye-peripheral, ithintele okanye inciphise intlungu enxulumene nentlungu ebangelwa I-Spimili. indlela yokuziphatha. Izifundo zeZilwanyana ziye zafumanisa ukuba i-Pregafalin inokuba nenjongo yokuzithemba kunye nee-opioids. I-Pregabalin ibonelela ngendlela entsha yonyango lweklinikhi lwentlungu ye-neuropathic.
Umatshini
I-Pregabalin inokunciphisa ukukhutshwa kwe-calcium ye-calcium yokukhutshwa kwee-neurotransmitters ngemodyuli yeCalcium Calnel Channel. Nangona i-Pregabalin iyinto ekhupha i-neurotranstom ye-neurotncitter acid (Gaba), ayizibophe ngqo kwi-Gabaa, i-Gabab, okanye eyandisa i-Gebaa ekuHlaleni i-Gebaa kwi-Gaba Ingqondo yeegundane, kwaye ayinayo ifuthe le-biba e-Gaba lokuthatha okanye ukonakaliswa. Nangona kunjalo, isifundo safumanisa ukuba i-neurons ixesha elide ka-Pegalisin yandisa ubuninzi bothutho lwe-GABA kunye nenqanaba lokuhamba kwe-Gaba. I-Pregabalin ayithinteli i-sodium itshati, ayisebenzi kwimisebenzi ye-opioid, ayisebenzi kwi-Degamine kunye ne-serotonin yokwamkela, kwaye ayithinteli ukwenziwa kweDogamine, i-serotonin, okanye i-norepinephrine. ingeniso.
Unxibelelwano lwamayeza
I-1. Ayisingafiyili yinkqubo yeCytochrome P450, ke, kunqabile ukuba idibane nezinye iziyobisi. Ayichaphazeli i-pharmacokinetics yeziyobisi ze-antiepileptic (ezinjenge-Sodium Volini, i-phenytoin, i-carbazerpine, i-carbazpine, i-phenobreepine, i-phenogline, i-phenoglycerate, yomlomo, kunye ne-insulin.
2. Xa le mveliso isetyenziswa kunye ne-oxycodone, umsebenzi wayo wokuqonda uya kuncitshiswa kwaye ukonakala komsebenzi wezithuthi kuya kuphuculwa.
3. Inefuthe elisongeneyo nge-lorazepam kunye ne-ethanol.
