I-rabemycin liyeza elivunyiweyo, i-anti-umhlaza kunye nokuchasana
Iinkcukacha zemveliso
| Igama | I-rabemycin |
| Inombolo ye-CAS | I-53123-88-9-9 |
| Ifomula yemolekyuli | C51h79no13 |
| Ubunzima bemolekyuli | I-914.19 |
| Inombolo ye-einecs | I-610-9655-5 |
| Indawo yokubila | I-799.83 ° C (iqikelelwe) |
| Ukuxinana | 1.0352 |
| Imeko yokugcina | Itywinwe kwi-freezer, engaphantsi kwe-42 ° C |
| Ifom | Umgubo |
| Umbala | Mhlophe |
| Ukupakisha | Ibhegi ye-PE + i-aluminium Bag |
Izithethantonye
I-AY 22989; 23,27-I-EUPOXY-3H-pyrido (2,1-C) (1,4) (i-1,4); i-rapa; i-rapa; i-rapa; i-RPM
Isiphumo se-Pharmacociological
Inkcazo
I-radiamycin yindawo yokulwa intsholongwane efana ne-procofol (fk506), kodwa inematshini eyahlukileyo kakhulu. I-FK506 ethintela ukwanda kwe-T LYMPhocytes evela kwinqanaba le-G0 isigaba se-G1, xa kuthelekiswa ne-CK506, i-Calping kwi-TK50, i-Calcium ixhomekeke kwi-Calcoundus-exhomekeke kwi-TARMPOCSTES. IYunivesithi yaseChicago Coustiners isebenzisa iitafile zeRamycin yomlomo kunye ne-Gramfriqe ijusi ye-eurothering ye-eurotherapy, eyayisa ukusinda kwezigulana. Izifundo zibonakalise ukuba i-rabemycin iyonyuselwa ngokulula yi-enzymes emva kokungena kwitreyini ye-Debang, kunye nejusi yediliya iqulethe isixa esikhulu se-suracomamarins, esinokuthi sithintele isiphumo se-ractmes yokugaya kwi-ractmes kwi-ractmes kwi-ractmes kwi-ractmes kwi-ractmes kwi-ractmes kwi-ractmes kwi-ractmes kwi-ractmes kwi-ractmes kwi-ractmes kwi-ractmes kwi-ractmes kwi-racymes kwi-ractmes kwi-ractmes kwi-ractmes kwi-ractmes kwi-ractmes kwi-ractmen. Inokuphucula i-bioaaaaiff ye-radiamycin. Kuthiwa ukuba oogqirha bamandulo bafumanise ukuba ijusi yeerandi inesiphumo sokuphucula ukwamkelwa komlomo kwisiseko somlomo, kwaye ngoku amazwe ase-European naseMelika asebenzise amalungiselelo eRamiamycin.
Kwiminyaka yakutshanje, izifundo ziye zafumanisa ukuba ithagethi ye-rabemycin (Mtor) yindawo ye-intracellilla, kunye nokungaqhelekanga kwendlela yayo kunokubangela izifo ezahlukeneyo. Njengomthi ojolise kuyo umT-mnumzana, iRamimycin inokunyanga i-thumbi esondelelene nendlela, kubandakanya umhlaza we-renal, umhlaza we-LIng, uMhlaza we-Liel, uMhlaza we-iuroendocrine kunye nomhlaza we-neuroendor. Ingakumbi kunyango lwezifo ezibini ezinqabileyo, i-LAM (LYMMMMMYHOOMAUTOIS) kunye ne-TSC (i-Scleus Scleorsis), impembelelo icacile kakhulu, kwaye i-LA kunye ne-TSC ingathathwa njengezifo zetoto ukuya kuthi ga kwinqanaba elithile.
Imiphumela
I-Rapumycin (Rapa) ineziphumo ebezingalindelekanga ezifanayo kwi-FK506. Kwinani elikhulu lovavanyo lweklinikhi, iziphumo ebezingalindelekanga zafunyanwa zixhomekeke kwi-Dose-ixhomekeke kwaye iguqukele umva, kwaye iRapa kwiidosi zonyango ayifunyanwanga ukuba ne-nephrotociciaty kwaye akukho thunzi i-charplasia. Eyona nto itywini nenetyhefu yetyhefu kunye nentloko, intloko, isicaphucaphu, isiyezi, iimpumlo, kunye nentlungu edibeneyo. I-Laboraries Acmormortor ibandakanya: i-rombocytopenia, leukopenia, i-Hypertrigrigrignia, Hyperglycemia, Hypomamia, Hypomamia, Hypomamia, i-Hypomamia, i-Hypomamia ichazwe nge-EdeE Ulawulo lwe-RAPA, kunye nonobangela wePlasma esezantsi yePlasma phosphate icingelwa ukuba i-Phosphate ixesha elide kwi-phosphate ye-phosphate ye-phosphate ye-phosphate ye-rablosphate ye-rapa-esekwe kunyango. Njenganye amanye amakhoboka, uRapa unethuba elongezelelekileyo losulelo, ngotyekelo oluchaziweyo lokunyusa inyumoniya, kodwa ukuvela kwesinye ithuba lokusuleleka alifani kakhulu kwi-CSA.
