I-RU-58841 Isetyenziswe njengoThintelo lokulahleka kweNwele kunye neMpatheni yobudoda
Iinkcukacha zeMveliso
| Igama | RU-58841 |
| Inombolo yeCAS | 154992-24-2 |
| Ifomula yemolekyuli | C17H18F3N3O3 |
| Ubunzima bemolekyuli | 369.34 |
| Inombolo ye-EINECS | 1592732-453-0 |
| Indawo yokubilisa | 493.6±55.0 °C(Kuqikelelwe) |
| Ukuxinana | 1.39 |
| Imeko yokugcina | Itywinwe kwindawo eyomileyo, Gcina kwisikhenkcisi, ngaphantsi kwe -20°C |
| Ifom | Umgubo |
| Umbala | Mhlophe |
| Ukupakisha | Ibhegi ye-PE + Ibhegi yeAluminiyam |
Izithethantonye
RU58841;4-(4,4-Dimethyl-2,5-dioxo-3-(4-hydroxybutyl)1-imidazolidinyl)-2-(trifluoromethyl)benzonitrile;4--[3-(4-Hydroxybutyl)-4,4-dimethyl-2,5-dioxo-1-imidazolidinyl-fluol]. i-onitrile;4--[3-(4-Hydroxybutyl)-4,4-diMethyl-2,5-dioxoiMidazolidin-1-yl]-2-(trifluoroMethyl) ben zonitrile;RU-58841E:candyli(at)speedgainpharma(dot)com;CS-637;RU588841;RU58841;RU58841;RU-58841
Isiphumo se-Pharmacological
Inkcazo
I-RU 58841 (PSK-3841) i-androgen receptor antagonist ekhuthaza ukukhula kweenwele.I-RU58841 lichiza lophando elenzelwe unyango oluchasene ne-androgenic alopecia, ekwaziwa ngokuba yimpandla yobudoda (MPD).
Njenge-topical anti-androgen, umgaqo wayo wesenzo awufani naleyo ye-finasteride. I-Finasteride isebenza ngokuthe ngqo kwi-5α reductase, inqanda ukuguqulwa kwe-testosterone kwi-DHT, kwaye iyanciphisa umxholo we-DHT emzimbeni. I-RU58841 ivimba umnxibelelwano phakathi kwe-dihydrotestosterone kunye ne-follicle receptors yeenwele, ayinciphisi ngokuthe ngqo umxholo we-DHT, kodwa iyanciphisa ukubopha kwe-DHT kunye ne-follicle receptors yeenwele, ukuze kufezekiswe injongo yokunyanga i-alopecia ye-androgenetic.
I-4--[3- (4-Hydroxybutyl) -4,4-dimethyl-2,5-dioxo-1-imidazolidinyl] -2-(trifluoromethyl) benzonitrile ingasetyenziswa njengeyeza I-Chemical synthesis intermediates.Ukuba i-4--[3- (4-hydroxybutyl) -4,4-dimethyl-2,5-dioxo-1-imidazolidinyl] -2-(trifluoromethyl) benzonitrile ifakwe umoya, Hambisa isigulane emoyeni omtsha;Kwimeko yokunxibelelana kwesikhumba, susa iimpahla ezingcolileyo, uhlambulule ulusu ngokucokisekileyo ngesepha kunye namanzi, kwaye ufune unyango ukuba kukho ukuphazamiseka;
Imiphumela
I-RU58841 isetyenziswe kwi-scalp, ifakwe kwi-follicles yeenwele, kwaye ithiyori, inokungena kwigazi kwaye ichaphazele ezinye iindawo zomzimba. Kodwa akukho ziphumo ebezingalindelekanga zenkqubo ezifunyenweyo kwizifundo zokusetyenziswa kwezihloko kwiinkawu. Nangona kunjalo, abanye abantu abaye bazama i-RU58841 bathi baye bafumana imiphumo enokubakho evela ekusebenziseni i-RU, kubandakanywa ukucaphuka kwesikhumba, ukunciphisa i-libido, ukungasebenzi kakuhle kwe-erectile, isicaphucaphu, amehlo abomvu, isiyezi kunye nentloko.
