I-tianeptine sodium ye-opisodes yoxinzelelo

Ukusetyenziswa

Isebenza ikakhulu kwinkqubo ye-5-ht, ngaphandle kwemincili, i-sedation, i-anti-acetylcholine kunye nentliziyo. Ngoxinzelelo.

Isiphumo se-Pharmacociological

I-1. Indlela yokulwa i-antidepress yale mveliso yahlukile kule ye-TCA yendabuko. Inokonyusa i-puttake ye-5-ht kwi-synaptic cleft, kodwa inefuthe elibuthathaka kwi-5-ht ne na. Inokuba nefuthe lokwandisa usulelo olu-5-ht neuranial. Ayinabubi bemihlayizana, H1, α1 kunye ne-α2-natoli.
2. Ukusebenza kakuhle kwemveliso yale mveliso kuyafana ne-TCA, kunye nokhuseleko lwayo kunye nokukhohlakala kungcono kune-TCA (i-tricycticlides). Ukusebenza kwale mveliso kuyafana ne-SSRI Fluoxetine.
3. Uvavanyo lweziyobisi lwezilwanyana lubonise ukuba: luyanyusa umsebenzi owaziwayo weeseli zepiramidal kwimvubu enkulu kwaye ikhawuleze iphinde ibuyiselwe kwakhona kwi-infinity; Yandisa ukuphinda kwenziwe kwakhona kwe-5-hydroxytrypypypypypypypypypypy nge-neurons kwi-Cestbral Cortex kunye neHippocampus.

Izifundo zeToolotyOlogy

-Ukuba, i-suble kunye neemvavanyo zexabiso zexabiso zebhayiloji, akukho msebenzi webhayoloji, umsebenzi we-PELR, i-atholotom anatomy.
- Uvavanyo lwetyhefu lokuzala kunye ne-teratogenicity: UTianegetity akanasiphumo kubuchule bokuzala babazali abanyangeleyo kunye nakuhlobo kunye nembewu.
Uvavanyo lwe-mutagenicity: UTianeptilo akanayo impembelelo.