Tirzepatide

Tirzepatide API
I-Tirzepatide yi-groundbreaking synthetic peptide esebenza njenge-agonist ezimbini zombini i-insulinotropic polypeptide exhomekeke kwi-glucose (GIP) kunye ne-glucagon-like peptide-1 (GLP-1) receptors. Imele iklasi entsha yonyango olusekwe kwi-incretin eyaziwa ngokuba yi-"twincretins", enikezela ngolawulo oluphuculweyo lwe-metabolic kwizigulana ezinesifo seswekile se-2 kunye nokutyeba.

I-API yethu ye-Tirzepatide iveliswa ngobuchule obuphambili bokwenziwa kweekhemikhali, iqinisekisa ubunyulu obuphezulu, amanqanaba asezantsi okungcola, kunye nokungaguquguquki okugqwesileyo kwebhetshi ukuya kwibhetshi. Ngokungafaniyo ne-rDNA-derived peptides, i-API yethu yokwenziwa ikhululekile kwiiprotheni zeeseli ze-host kunye ne-DNA, iphucula kakhulu i-biosafety kunye nokuthotyelwa kokulawula. Inkqubo yokwenziwa kwemveliso iye yalungiselelwa ukonyuswa ukuhlangabezana nemfuno ekhulayo yehlabathi.

Indlela yokwenza
I-Tirzepatide isebenza ngaxeshanye ivuselela zombini i-GIP kunye ne-GLP-1 receptors, ibonelela ngeziphumo ezihambelanayo kunye ne-synergistic:

Ukusebenza kwe-receptor ye-GIP: kuphucula ukukhutshwa kwe-insulin kwaye kunokuphucula ukuvakalelwa kwe-insulin.

I-GLP-1 receptor activation: icinezela ukukhutshwa kweglucagon, ilibazisa ukuphuma kwesisu, kwaye inciphisa umdla wokutya.

Umsebenzi odibeneyo ukhokelela ku:

Ukuphuculwa kolawulo lwe-glycemic

Ukunciphisa umzimba

Ukuhlutha okuphuculweyo kunye nokuncitshiswa kokutya

Uphando lwezonyango kunye neziphumo
I-Tirzepatide ibonise ukusebenza ngendlela engazange ibonwe ngaphambili kwizilingo ezininzi zeklinikhi ezinkulu (SURPASS & SURMOUNT series):

Ukunciphisa okuphezulu kwe-HbA1c xa kuthelekiswa ne-GLP-1 RAs (umzekelo, iSemaglutide)

Ukunciphisa umzimba ukuya kwi-22.5% kwizigulane ezityebileyo - ezifaniswa nokuhlinzwa kwe-bariatric kwezinye iimeko

Ukuqala ngokukhawuleza kwempembelelo kunye nokulawulwa kwe-glycemic ehlala ixesha elide ekusebenziseni ixesha elide

Iimpawu eziphuculweyo ze-cardiometabolic: kubandakanywa uxinzelelo lwegazi, i-lipids, kunye nokudumba

I-Tirzepatide ayitshintshi kuphela i-paradigm yonyango yohlobo lwe-2 yeswekile kodwa iphinda ivele njengeyona ndlela yonyango yokunciphisa umzimba kunye nesifo se-metabolic syndrome.

Umgangatho & Ukuthotyelwa
ITirzepatide API yethu:

Idibana nemigangatho yomgangatho wehlabathi (FDA, ICH, EU)

Ivavanywe nge-HPLC kumanqanaba asezantsi okungcola okwaziwayo nokwaziwa

Yenziwe phantsi kweemeko ze-GMP ngamaxwebhu enkqubo epheleleyo

Xhasa imveliso enkulu yeR&D