IVancomycin sisithinteli-ntsholongwane se-glycopeptide esisetyenziselwa i-antibacterial
Iinkcukacha zeMveliso
| Igama | Vancomycin |
| Inombolo yeCAS | 1404-90-6 |
| Ifomula yemolekyuli | I-C66H75Cl2N9O24 |
| Ubunzima bemolekyuli | 1449.25 |
| Inombolo ye-EINECS | 215-772-6 |
| Ukuxinana | 1.2882 (uqikelelo olurhabaxa) |
| Isalathiso sokuqhafaza | 1.7350 (uqikelelo) |
| Iimeko zokugcina | Itywinwe kwindawo eyomileyo, 2-8°C |
Izithethantonye
Vancomycin(base kunye/orunspecifiedsalts);VANCOMYCIN;VancomycinBase;(3S,6R,7R,22R,23S,26S,36R,38aR) -3-(2-Amino-2-oxoethyl)-44-[[2-O-(3-amino-2, 3,6-trideoxy-3-C-methyl-α-L-lyxo-hexopyranosyl)-β-D-glucopyranosyl]oxy]-10,19-dichloro-2,3,4,5,6,7,23,24,25,26,36,37,38,38a-7a-7 ,22,28,30,32-pentahydroxy-6-[[(2R)-4-methChemicalbookyl-2-(methylamino)-1-oxopentyl]amino]-2,5,24,38,39-pentaoxo-22H-8,11:18,21-Dietheno-23, 36-(iminomethano) -13,16:31,35-dimetheno-1H,16H-[1,6,9]oxadiazacyclohexadecino[4,5-m][10,2,16]benzoxadiazacyclotetracosine-26-carboxylicacid.
Inkcazo
IVancomycin sisithinteli-ntsholongwane se-glycopeptide. Indlela yokusebenza kwayo kukubopha ngokusondelelana okuphezulu kwi-alanylalanine kwisiphelo se-poly-terminal ye-precursor peptide yodonga lweseli yebhaktiriya enovakalelo, ukuthintela ukuhlanganiswa kwe-macromolecular peptidoglycan eyenza udonga lweseli yebhaktiriya, okukhokelela ekutshabalaleni kodonga lweseli kubulala ibhaktheriya. IVancomycin iyasebenza kusulelo olumandundu olubangelwa yintsholongwane yeGram-positive, ngakumbi ezo zibangelwa yi-methicillin-resistant Staphylococcus aureus, Staphylococcus epidermidis, kunye ne-Enterococcus ezixhathisayo kwezinye izibulala-ntsholongwane okanye ezingasebenzi kakuhle.
Iimpawu
Inqunyelwe kwizifo zenkqubo ezibangelwa yi-methicillin-resistant Staphylococcus aureus (MRSA) kunye nokusuleleka kwamathumbu emathunjini kunye nezifo zenkqubo ezibangelwa yiClostridium difficile; izigulane ze-penicillin-alergic azikwazi ukusebenzisa i-penicillins okanye i-cephalosporins kwizigulane ezinosulelo olunzima lwe-staphylococcal, okanye abo banosulelo olunzima lwe-staphylococcal abangakwazanga ukuphendula kwi-antibiotics engentla, i-vancomycin ingasetyenziswa. Le mveliso ikwasetyenziselwa unyango lwe-Enterococcus endocarditis kunye ne-Corynebacterium (i-Diphtheria-like) endocarditis kubantu abachasene ne-penicillin. Unyango lwe-staphylococcus-induced arteriovenous shunt infections kwi-hemodialysis izigulane ezingahambisani ne-penicillin kunye ne-non-allergic to penicillin.
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