I-Cetrorelix Acetate yokuthintela i-Ovulation ngaphambi kwexesha 120287-85-6
Iinkcukacha zeMveliso
| Igama | Cetrorelix acetate |
| Inombolo yeCAS | 120287-85-6 |
| Ifomula yemolekyuli | I-C70H92ClN17O14 |
| Ubunzima bemolekyuli | 1431.04 |
| Inombolo ye-EINECS | 686-384-6 |
Izithethantonye
AC-(D-ALA[3-(2-NAPHTHYL)])-[D-PHE(4-CL)]-(D-ALA[3-(3-PYRIDYL)])-SER-TYR-(D-CIT)-LEU-ARG-PRO-D-ALA-OH;Cetrorelixacetate;CETRORELIHLOHLO;CETRORELIHLOKO;CETRORELIHLOM;CETRORELICEDRICEDRICEDRICEDRIXEDRIXRIXEDRIXRIXRIXRIXRIX; hemicalbookN-Acetyl-3-(2-naphthalenyl)-D-Ala-4-chloro-D-Phe-3-(3-pyridyl)-D-Ala-L-Ser-L-Tyr-N5-(aminocarbonyl)-D-Orn-L-Leu-L-Arg-L-Pro-D-CemtroliNH;
Inkcazo
I-Cetrorelix acetate yi-synthetic decapeptide, esetyenziswa kakhulu ekuncediseni iteknoloji yokuzala ukukhusela i-ovulation ngaphambi kwexesha kwizigulane ezinokulawulwa kwe-ovarian stimulation. I-gonadotropin-releasing hormone (GnRH) i-antagonist enokuthi ikhuphisane ne-LHRH engapheliyo ukuze ibophe kwi-receptors kwi-membrane yeseli ye-pituitary, ngaloo ndlela inqanda ukukhutshwa kwehomoni ye-luteinizing (LH) kunye ne-follicle stimulating hormone (FSH) yi-pituitary ngendlela exhomekeke kwidosi.
I-Cetrorelix acetate ngumchasi we-gonadotropin-releasing hormone (GnRH). Le mveliso ikhuphisana ne-GnRH engapheliyo ye-receptors kwiiseli ze-pituitary, ngaloo ndlela inqanda ukukhutshwa kwehomoni ye-luteinizing engapheliyo (LH) kunye ne-follicle-stimulating hormone (FSH), ukulibazisa ukubonakala kwe-LH ephezulu, ngaloo ndlela ilawula i-ovulation. Umphumo wale mveliso uxhomekeke kwi-dose, i-inhibitory effect ngokuthe ngqo, kwaye igcinwe ngonyango oluqhubekayo, ngaphandle kokubangela ukwanda kokuqala komsebenzi we-progesterone receptor olandelwa kukuncipha.
Izixhobo ezivela kwiSebe loMgangatho
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I-TOC kunye ne-Conductivity
I-TOC kunye ne-conductivity yobonelelo oluphambili kunye neendawo zokubuya zibekwe esweni ngamaxesha athile. I-TOC ibekwe esweni yi-QC veki nganye. I-Conductivity ijongwa kwi-intanethi kwaye irekhodwa ngumsebenzisi wesikhululo samanzi acociweyo kanye ngeyure ezine. I-conductivity ibekwe esweni kwi-RO ephambili, i-RO yesibini, i-EDI kunye ne-total return point of distribution system. Iinkcukacha zamanzi acociweyo zikhona kwaye zihambelana neenkcukacha ezichazwe kwangaphambili ezingadluli kwi-1.3 µs/cm kuma-25°C (USP). Kubonelelo oluphambili kunye namanqaku okubuyisela, uvavanyo olupheleleyo. lwenziwa veki nganye, kwezinye iindawo zokusebenzisa kwi-loop ejikelezayo, uvavanyo olupheleleyo lwenziwa kanye ngenyanga. Uvavanyo olupheleleyo lubandakanya abalinganiswa, i-pH, i-nitrate, i-nitrite, i-ammonia, i-conductivity, i-TOC, izinto ezingaguqukiyo, isinyithi esinzima, imida ye-microbial kunye ne-endotoxin yebhaktheriya.
