Ganirelix Acetate Peptide API
Iinkcukacha zeMveliso
| Igama | Ganirelix Acetate |
| Inombolo yeCAS | 123246-29-7 |
| Ifomula yemolekyuli | I-C80H113ClN18O13 |
| Ubunzima bemolekyuli | 1570.34 |
Izithethantonye
Ac-DNal-DCpa-DPal-Ser-Tyr-DHr(Et2)-Leu-Har(Et2)-Pro-DAla -NH2;Ganirelixum;ganirelix Acetate; GANIRELIX; Ganirelix Acetate USP/EP/
Inkcazo
I-Ganirelix yi-synthetic decapeptide compound, kunye netyuwa ye-acetate, i-Ganirelix acetate yi-gonadotropin-releasing hormone (GnRH) i-antagonist ye-receptor. Ukulandelelana kwe-amino acid yile: Ac-D-2Nal-D-4Cpa-D-3Pal-Ser-Tyr-D-HomoArg(9,10-Et2)-Leu-L-HomoArg(9,10-Et2)-Pro-D- Ala-NH2. Ikakhulu ngokweklinikhi, isetyenziswa kubasetyhini abafumana itekhnoloji yokuncedisa ekuzaleni elawulwa ziinkqubo zokuvuselela i-ovarian ukunqanda incopho yehomoni ye-luteinizing ngaphambi kwexesha kunye nokunyanga ukuphazamiseka kokuzala ngenxa yesi sizathu. Ichiza lineempawu zokusabela okungathandekiyo, izinga eliphezulu lokukhulelwa kunye nexesha elifutshane lonyango, kwaye lineenzuzo ezicacileyo xa kuthelekiswa namachiza afanayo kunyango lweklinikhi.
Isenzo se-Pharmacological
Ukukhutshwa kwe-pulsatile ye-gonadotropin-releasing hormone (GnRH) ivuselela ukudibanisa kunye nokukhupha i-LH kunye ne-FSH. I-frequency ye-LH pulses kwi-mid and late follicular phases imalunga ne-1 ngeyure. Ezi pulses zibonakaliswa ngokunyuka okwethutyana kwi-serum LH. Ngexesha lexesha eliphakathi lokuya exesheni, ukukhutshwa okukhulu kwe-GnRH kubangela utyando lwe-LH. Utyando lwe-LH lwaphakathi exesheni lunokubangela iimpendulo ezininzi zomzimba, ezibandakanya: ukukhutshwa kweqanda, ukuqalisa kwakhona kwe-oocyte meiotic, kunye nokwakheka kwe-corpus luteum. Ukuqulunqwa kwe-corpus luteum kubangela ukuba amanqanaba e-serum progesterone anyuke, ngelixa amanqanaba e-estradiol ehla. I-Ganirelix i-acetate ngumchasi we-GnRH okhuphisana ngokuvimba i-GnRH i-receptors kwi-pituitary gonadotrophs kunye neendlela zokudluliselwa okulandelayo. Ivelisa ngokukhawuleza, ukubuyisela ukuguqulwa kwe-gonadotropin secretion. Impembelelo yokuthintela ye-ganirelix acetate kwi-pituitary LH secretion yayinamandla kunaleyo kwi-FSH. I-Ganirelix acetate ayiphumelelanga ukukhuthaza ukukhutshwa kokuqala kwe-gonadotropins engapheliyo, ehambelana nokuchasana. Ukuchacha ngokupheleleyo kwe-pituitary LH kunye namanqanaba e-FSH kwenzeka kwiiyure ezingama-48 emva kokuba i-ganirelix acetate iyekwa.
