I-PaclitaXel 33069-62-4-4-4-4-4-4-4-4 i-anti-tumation iyeza lezonyango le-ovarian yomhlaza we-ovarian, umhlaza wamabele
Iinkcukacha zemveliso
| Igama | I-PaclitaXel |
| Inombolo ye-CAS | I-33069-62-42-4 |
| Ifomula yemolekyuli | C47h51no14 |
| Ubunzima bemolekyuli | I-853.92 |
| Inombolo ye-einecs | 608-826-9 |
| Indawo yokubila | I-774.66 ° C (iqikelelwe) |
| Ukuxinana | I-0.200 |
| Imeko yokugcina | Itywinwe kwi-freezer, i-2-8 ° C |
| Ifom | Umgubo |
| Umbala | Mhlophe |
| Ukupakisha | Ibhegi ye-PE + i-aluminium Bag |
Izithethantonye
I-PaclimaXel HCL; I-PACLITAXEL (indalo); i-paclitaXelx; n-benzyl-phenguxalline, i-pactrifothision, i-pactringaxol; paclitaxel
Isiphumo se-Pharmacociological
Inkcazo
I-Paclitricaxel i-sutomeric diterpenoid ikhutshwe kwi-bark ye-teks ye-teks yendalo. Ukulandelwa kwe-isotope kubonise ukuba i-paclimaXal ibotshelelwe kwi-microtubulles ye-polymermed kwaye ayisaphendulanga ngama-sublin kaTublin. Emva kokuba iiseli ziboniswe kwi-paclitaxel, inani elikhulu lee-microtubules ziya kuqokelelwa kwiiseli. Ukuqokelelwa kwezi Microrubules kuyaphazamisa imisebenzi eyahlukeneyo yeseli, ngakumbi ukwahlula kweseli kuyamisa kwiSigaba seMittic kunye neebhloko zokuqhekelwa kwecandelo leseli. Ngophando lweklinikhi ye-ⅱ-ⅲ, i-pactritaxel ilungele umhlaza we-ovari kunye nomhlaza webele, kwaye inefuthe lomhlaza wemiphunga, i-coloretal umhlaza, umhlaza wentamo, i-tumar yengqondo.
Iphawu
Inefuthe elihle kunyango lomhlaza we-ovari kunye neplatinam kunye nombulelo womhlaza we-ovaris kunye nomhlaza webele. Umhlaza, umhlaza ongaphezulu we-gestrointentinal, iselfowuni encinci kunye neseli-ne-un-mungs encinci encinci inombono olungileyo.
Ukulungisa
Sebenzisa i-1: I-Brict-Rer-tumacalicals ze-ovarian yomhlaza we-ovarian, umhlaza webele, njl.
Sebenzisa i-2: i-antict-burm-tumacalicals zonyango lomhlaza we-ovari, umhlaza wamabele kunye nezinye izifo.
Sebenzisa i-3: iziyobisi ze-antiormumer. Ukunyanga umhlaza we-metastatitic ibele kunye nomhlaza we-ovariatian ovariki. I-Anti-Speectrium Anti-Tumicals Sochoicals zonyango lomhlaza we-ovari, umhlaza wamabele kunye nezinye izifo.
Sebenzisa i-4: iZiyobisi ezifanelekileyo ze-Anti-Tumor; I-Binds kwi-N-tublin yendawo ye--tubhalin, ikhuthaza imingxunya yokuzimasela kakhulu i-microcububle, ixhathise i-depolymerization, ithintela ukwahlula-hlulwa kwezinto eziqhelekileyo kunye nemigibe kwi-G2 / M isigaba se-G2 / M sibe ngumjikelo we-G2 / M.
Sebenzisa i-5: ichiza le-anti-microrubule, ukuthintela i-depolymerizotion ngokukhuthaza i-tublin polymerizazation, ukugcina uzinzo lwe-tublin, kunye nokuvula i-ittosis yeseli.
