Pulegone

Pulegone API

I-Pulegone (ifomula ye-molecular: C₁₀H₁₆O) yi-monoterpene ketone compound ephuma kwizityalo zendalo ze-oyile ezibalulekileyo, ezifumaneka ngokubanzi kwi-mint (Mentha), i-verbena (i-Verbena) kunye nezityalo ezinxulumene nazo. Njengesithako sendalo esinevumba elimnandi kunye nomsebenzi ophezulu webhayoloji, uPulegone ufumene ingqwalasela ebanzi kumayeza endalo, izibulali-zinambuzane zebhotani, iikhemikhali ezisebenzayo zemihla ngemihla kunye nezixhobo ezikrwada zamayeza kwiminyaka yakutshanje.

I-API ye-Pulegone esiyinikezelayo yi-compound yococeko oluphezulu olufunyenwe ngokuhlukana ngokufanelekileyo kunye nenkqubo yokuhlanjululwa, ehlangabezana nemigangatho yemigangatho yamayeza okanye amabakala oshishino kwaye ifanelekile kwiindidi ezahlukeneyo zokusetyenziswa ezifana nophando lwezesayensi kunye nophuhliso kunye nokudibanisa okuphakathi.

Imvelaphi yophando kunye nefuthe le-pharmacological

1. Impembelelo yokuchasa

Inani elikhulu lezilwanyana kunye nezifundo zokuhlola iiseli ziye zafumanisa ukuba i-Pulegone inokuthintela ukukhululwa kwezinto eziphazamisayo (ezifana ne-TNF-α, IL-1β kunye ne-IL-6), lawula iindlela zokubonisa i-COX-2 kunye ne-NF-κB, kwaye ngaloo ndlela ubonise amandla okulwa nokuvuvukala kwiimodeli zezifo ezifana ne-rheumatoid arthritis kunye nokuvuvukala kwesikhumba.
2. I-analgesic kunye nemiphumo ye-sedative

I-Pulegone inempembelelo ethile yokuthintela kwinkqubo ye-nervous central kwaye ibonisa umphumo ocacileyo we-analgesic kwiimodeli zezilwanyana. Indlela yayo inokunxulumana nokulawulwa kwenkqubo ye-neurotransmitter ye-GABA. Inamandla okusetyenziswa njengonyango lwe-adjuvant yokukhathazeka kancinci okanye intlungu ye-neuropathic.
3. Umsebenzi we-Antibacterial kunye ne-antifungal

I-Pulegone ineempembelelo ezithintelayo kwiindidi ze-Gram-positive kunye ne-Gram-negative bacteria, njenge-Staphylococcus aureus, i-Escherichia coli, i-Bacillus subtilis, njl.; ikwabonisa isakhono sokuthintela ukungunda okufana ne-Candida albicans kunye ne-Aspergillus, kwaye ifanelekile kuphuhliso lwezithinteli zendalo kunye neemveliso ezichasene nezifo ezisekelwe kwizityalo.
4. Umsebenzi wokugxotha izinambuzane kunye nezibulala-zinambuzane

Ngenxa yempembelelo yayo yokuthintela kwinkqubo ye-nervous yezinambuzane, i-Pulegone isetyenziswa kakhulu kwizityalo zendalo ezigxotha izinambuzane, ezinokugxotha ngokufanelekileyo iingcongconi, amangolwane, iimpukane zeziqhamo, njl.
5. Umsebenzi onokwenzeka wokulwa ne-tumor (uphando lokuqala)

Uphononongo lokuqala lubonise ukuba i-Pulegone inokuba nefuthe elithintelayo kwezinye iiseli zethumba (ezifana neeseli zomhlaza wamabele) ngokubangela i-apoptosis, ukulawula uxinzelelo lwe-oxidative kunye nomsebenzi we-mitochondrial, njl.
Iinkalo zesicelo kunye neziphumo ezilindelekileyo
●Ishishini lamachiza

Njengemolekyuli ekhokelayo yendalo ekuphuhlisweni kweziyobisi, i-Pulegone ingasetyenziselwa njengendawo ephakathi ukuthatha inxaxheba kwi-synthesis ye-menthol (i-Menthol), i-menthone, izongezo ze-flavour kunye ne-anti-inflammatory and antibacterial new drug. Inamathemba osetyenziso olubanzi ekuphuculweni kwamayeza emveli aseTshayina kunye namalungiselelo endalo amachiza.
●Izithambiso kunye neekhemikhali zemihla ngemihla

Ngobumnandi bayo kunye nomsebenzi wokulwa ne-antibacterial, i-Pulegone isetyenziselwa ukulungisa imilomo yendalo, i-mouthwashs, i-antiseptic washs, i-mite sprays, iimveliso zokugxotha iingcongconi, njl.
●Ezolimo kunye nezinto ezigxotha izinambuzane ezisingqongileyo

I-Pulegone, njengesithako se-insecticide yendalo, isetyenziselwa ukuphuhlisa izitshabalalisi ezisekelwe kwizityalo ezifunekayo kwi-organic Agriculture, ukunciphisa ukungcoliseka kwendalo, ukuphucula umgangatho wezityalo, kunye nokuthobela isicwangciso sophuhliso lwezolimo oluzinzileyo.
Ukuzibophelela komgangatho weGentolex Group

IPulegone API ebonelelwe liQela lethu leGentolex ineziqinisekiso zomgangatho zilandelayo:

Ukucoceka okuphezulu: ukucoceka ≥99%, ifanelekile kumachiza kunye nokusetyenziswa kwamashishini aphezulu

Iyahambelana ne-GMP kunye neemfuno zenkqubo yolawulo lomgangatho we-ISO

Ukubonelela ngeengxelo zokuhlola umgangatho obanzi (i-COA, kubandakanywa uhlalutyo lwe-GC / HPLC, isinyithi esinzima, i-solvents eshiyekileyo, imida ye-microbial)

Iinkcazo ezenziwe ngokwezifiso zinokubonelelwa ngokweemfuno zabathengi, ukubonelela ngenkxaso ukusuka kwiigram ukuya kwiikhilogram