I-Semaglutide ye-Type 2 Diabetes
Iinkcukacha zeMveliso
| Igama | Semaglutide |
| Inombolo yeCAS | 910463-68-2 |
| Ifomula yemolekyuli | C187H291N45O59 |
| Ubunzima bemolekyuli | 4113.57754 |
| Inombolo ye-EINECS | 203-405-2 |
Izithethantonye
I-Sermaglutide; I-Semaglutide fandachem; ukungcola kweSemaglutide; I-Sermaglutide USP/EP; i-semaglutide; I-Sermaglutide CAS 910463 68 2; Ozempic,
Inkcazo
I-Semaglutide sisizukulwana esitsha se-GLP-1 (i-glucagon-like peptide-1) analogues, kwaye i-semaglutide yifom yedosi yexesha elide ephuhliswe ngokusekelwe kwisiseko esisisiseko se-liraglutide, enempembelelo engcono kunyango lwe-2 yeswekile. I-Novo Nordisk iye yagqiba izifundo ze-6 zeSigaba se-III se-semaglutide injection, kwaye yangenisa isicelo esitsha sokubhaliswa kweziyobisi kwi-semaglutide i-injection yeveki kwi-US Food and Drug Administration (FDA) ngoDisemba 5, 2016. Isicelo se-Marketing Authorization Application (MAA) nayo yathunyelwa kwi-European Medicines Agency (EMA).
Xa kuthelekiswa ne-liraglutide, i-semaglutide ine-aliphatic chain ende kunye nokunyuka kwe-hydrophobicity, kodwa i-semaglutide iguqulwa ngekhonkco elifutshane le-PEG, kwaye i-hydrophilicity yayo iphuculwe kakhulu. Emva kokuguqulwa kwe-PEG, ayikwazi nje ukubopha ngokusondeleyo kwi-albumin, igubungele indawo ye-enzymatic hydrolysis ye-DPP-4, kodwa iphinde inciphise ukukhutshwa kwezintso, ukwandisa ixesha le-biological half-life, kunye nokufezekisa umphumo wokujikeleza ixesha elide.
Isicelo
I-Semaglutide yindlela yokulinganisa ixesha elide eliphuhliswe ngokusekelwe kwisiseko esisisiseko se-liraglutide, esisebenza ngakumbi ekuphatheni uhlobo lwe-2 yeswekile.
Ukusebenza kwezinto eziphilayo
I-Semaglutide (i-Rybelsus, i-Ozempic, i-NN9535, i-OG217SC, i-NNC0113-0217) i-glucagon-efana ne-peptide ye-1 (GLP-1) i-analog, i-agonist ye-GLP-1receptor, kunye nohlobo olunokubakho lwe-2 I-Therapeutic efficacy (T2DM mellitus) yesifo sikashukela.
Inkqubo yoMgangatho
Ngokubanzi, inkqubo yomgangatho kunye nesiqinisekiso sikhoyo sibandakanya onke amanqanaba okuveliswa kwemveliso egqityiweyo. Imisebenzi eyaneleyo yokwenziwa kwemveliso nolawulo iyenziwa ngokuhambelana neenkqubo/inkcukacha ezivunyiweyo. Ulawulo lotshintsho kunye nenkqubo yokuphatha ukutenxa ikhona, kwaye uvavanyo lwempembelelo oluyimfuneko kunye nophando lwenziwa. Iinkqubo ezifanelekileyo zikhona ukuqinisekisa umgangatho wemveliso ngaphambi kokuba ikhululwe kwimarike.
