I-Sildenafil Citrate yoNyango lwe-Erectile Dysfunction 171599-83-0
Iinkcukacha zeMveliso
| Igama | I-Sildenafil Citrate |
| Inombolo yeCAS | 171599-83-0 |
| Ifomula yemolekyuli | I-C28H38N6O11S |
| Ubunzima bemolekyuli | 666.70 |
| Inombolo ye-EINECS | 200-659-6 |
| Merck | 14,8489 |
| Ukuxinana | 1.445g/cm3 |
| Imeko yokugcina | 2-8°C |
| Ifom | Umgubo |
| Umbala | Mhlophe |
| Ukunyibilika kwamanzi | I-DMSO: > 20mg/mL |
Izithethantonye
Viagra,Sildenafil citrate; 1-[[3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl] -4-methylpiperazinecitratesalt; 5-[2-Ethoxy-5- (4-methylpiperazin-1-yl) sulfonylphenyl] -1-methyl-3-propyl-4H-pyrazolo [5,4-e] pyrimidin-7-onecitratesalt; 1-[[3-(6,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine,2-hydroxy-1,2,3-propanetricarboxylate; SildenafilCitrate(100mg); Sildenafilcitrate,>=99%;Sildenafilcitrate,Professionalsupply; 5-[2-Ethoxy-5-[(4-methyl-piperazin-1-yl)sulfonyl]phenyl] -1,6-dihydro-1-methyl-3-propyl-7H-pyrazolo[4,3-d]pyrimidin-7-onecitrate
Isiphumo se-Pharmacological
Isenzo se-Pharmacological
I-Sildenafil citrate yinto ekhethiweyo ye-5-phosphodiesterase inhibitor eyenza i-nitric oxide-dependent, i-cyclic guanosine monophosphate-mediated pulmonary vasodilation ngokuvimbela ukuchithwa kwe-cyclic guanosine monophosphate. Ukongeza kokwandiswa ngokuthe ngqo kwemithambo yegazi ye-pulmonary, kunokuthintela okanye ukuguqula ukulungiswa kwe-vascular.
Iipropati zonyango kunye nezicelo
I-Sildenafil citrate, igama lokurhweba i-Viagre, eyaziwa ngokuba yi-Viagra, i-cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) inhibitor enokuphucula ukulungiswa emva kokulawulwa komlomo. I-Sildenafil citrate inokuphucula umphumo we-nitric oxide (NO) ngokuvimbela uhlobo lwe-5 phosphodiesterase oluchitha i-cyclic guanosine monophosphate (cGMP) kwi-corpus cavernosum. Ukwandisa inqanaba le-cGMP kwi-corpus cavernosum, phumla i-muscle egudileyo kwi-corpus cavernosum, ukwandisa ukungena kwegazi, ukwandisa ixesha lokumisa i-penis kunye nokwandisa ukuqina. Kwizigulana ezingenamandla kunye ne-erectile dysfunction. Abantu abadala bathatha i-50 mg ngomlomo ngexesha ngalinye, ukuya kwi-1 ixesha ngosuku, kwaye bayisebenzise njengoko kufuneka malunga neyure ye-1 ngaphambi kokulala ngesondo. Ubuninzi bexabiso yi-0.1g ngexesha ngalinye.
Kwizifundo ze-vivo
Kwizinja ze-anesthetized, i-Sildenafil citrate iphucula umsebenzi we-penile erectile phantsi kwe-pelvic nerve stimulation ngokulinganisa uxinzelelo lwe-intracavernous. I-Sildenafil citrate iguqule ngokuphawulekayo ukuguqulwa kokuphazamiseka kwe-carbamoylcholine-ukuvuselela ukuphumla kunye nokuthintela ukubunjwa kwe-superoxide kwizicubu ze-cavernosal zoonogwaja be-hypercholesterolemic. Kwiigundane ze-Sprague-Dawley, i-Sildenafil iphucula umsebenzi we-erectile ngexesha elixhomekeke kwi-dose-time, kunye nokubuyiselwa okuphezulu okwenzeka ngosuku lwe-28 kwi-dose ye-20 mg / kg ngosuku. Kwiigundane ze-Sprague-Dawley, ukulawulwa kwe-Sildenafil kubangele ukugcinwa kwe-collagen ye-muscle epholileyo kunye nokugcinwa kwe-CD31 kunye ne-eNOS expression. Kwiigundane ze-Sprague-Dawley, i-Sildenafil yanciphisa kakhulu i-apoptotic index kwaye yandisa i-phosphorylation ye-akt kunye ne-eNOS xa kuthelekiswa neqela lokulawula.
