I-SIDDENAPIL i-Gicerate Ukunyanga ukungasebenzi kakuhle kwe-171599-83-0
Iinkcukacha zemveliso
| Igama | I-SIDENAPIL ICICRARLE |
| Inombolo ye-CAS | 171599-83-0 |
| Ifomula yemolekyuli | C28h38n6N6O11s |
| Ubunzima bemolekyuli | I-666.70 |
| Inombolo ye-einecs | Ngo-200-659-6 |
| Merck | I-14,8489 |
| Ukuxinana | 1.445G / CM3 |
| Imeko yokugcina | I-2-8 ° C |
| Ifom | Umgubo |
| Umbala | Mhlophe |
| Ukungathobeli kwamanzi | I-DMSO:> 20mg / ml |
Izithethantonye
I-Viagra, i-Silnafil dirate; 1 - [[3- (4,7-I-Dihydl-7-I-Ogopyl-1h-pyrazol] -4-I-ETTYLPUPUPEALT; 5- [2-ETHEXY-5) 1 - [[3- (6,7-I-Thydyl-7-I-Oxo-Papypyl] -4-I-ETTYLPIPEL] - I-SIDDENILCIITRACRARE (100mg); Sildenafilcitrate,>=99%;Sildenafilcitrate,Professionalsupply; 5- [2-ETHEXY-5 - [
Isiphumo se-Pharmacociological
Inketho ye-Pharmacological
I-SIDENENAPIL CITTE yi-5-phosphodiesterase inhibit exhomekeke kwi-nitric-ixhomekeke kwi-nitric oxide-i-vasmoninary vasodial vasmonphary-vasmoning vasmonphary up puanosphate ye-cyclic guafosphate. Ukongeza kokwandiswa ngokuthe ngqo kwemithambo yegazi ye-pulmonary, inokunqanda okanye iphinde ibuye umva.
Iipropathi zonyango kunye nezicelo
I-SIDENENAPIL i-gitterite, igama lorhwebo Viagre, eliqhelekileyo njenge-viagra, yi-cyclic guafosphate (cgmp) uphossictrase ye-5 (i-CGMPICCICCECECESTECERAse) yoLungu loLwakhiwo. I-SIDENENAPIL CITRE CITE inokuphucula isiphumo se-nitric oxide (hayi) ngokuthintela uhlobo 5 phosphodiesterase ovelisa i-monophosphate yaseCorpus. Yongeza inqanaba le-CGMP kwi-Corpus Cavernosum, phumza umsipha ogudileyo kwi-Corpus Cevernosum, wande ukwandisa igazi, ukwandisa ixesha lokwakha i-penis kunye nokwandisa ukuqina. Ngeegulana ezingalinganiyo nezihlobo ze-erectile. Abantu abadala bathatha i-50 mg ngomlomo nganye, ukuya kuthi ga nge-1 ngosuku, kwaye bayisebenzise njengoko kufuneka malunga neyure enye ngaphambi kokuba neentlobano zesini. Esona sixa siphezulu yi-0.1g qho.
Kwizifundo ze-VIVO
Kwizinja ezisetyenziswayo, i-SIDENAFISIL i-gicterate yandisa umsebenzi we-Pelvile ye-Pelvic Providences kwi-Pelvic Feling ngokulinganisa uxinzelelo lwe-intraalnovernous. I-SIDDENAPIL i-Citite i-Citroltive ibuyiselwe ukuphumla kwe-Carbsamoyline yokuphumla kunye nokuvalwa kwe-superoxide kwi-fupernosal yezicubu ze-chypercolesterolemic. Kwi-sprague-dawley rats, i-SIDENEAFIL iphucula ukusebenza kwe-irectile ngendlela exhomekeke kwi-dose-exhomekeke kwi-Dose-Pouseres, ngokutsha kwenzeke ngomhla wama-20 kwidosi ye-20 mg / kg ngemini. Kwi-sprague-dawley rats, ulawulo lwe-SIDANEANISL luye lwaphumela ekulondolozeni umlinganiso womsipha kunye nokulondolozwa kwe-CD31 kunye nentetho ye-Enos. Kwi-sprague-dawley rats, i-saldenafil inciphise indeptotivel yesalathiso kwaye inyuse inkangeleko ye-AKT kunye ne-EFY xa kuthelekiswa neqela lolawulo.
