Ste-γ-Glu-AEEA-AEEA-OSU

Ste-γ-Glu-AEEA-AEEA-OSU

I-Ste-γ-Glu-AEEA-AEEA-OSU yi-synthetic lipidated linker molecule eyenzelwe ukuhanjiswa kwechiza ekujoliswe kulo kunye ne-antibody-drug conjugates (ADCs). Ibonisa umsila we-stearoyl (Ste) we-hydrophobic, i-γ-glutamyl ejoliswe kuyo, i-AEEA spacers yokuguquguquka, kunye neqela le-OSu (NHS ester) lokudibanisa ngokufanelekileyo.

 
Uphando & nezicelo:

Isetyenziswe kwi-prodrug synthesis ekujoliswe kuyo kunye noyilo lwe-nanocarrier

Yandisa intsebenziswano ye-cell membrane kunye nokufunyanwa kweziyobisi

Iququzelela ukuncamatheliswa komthwalo wesayithi ngokuthe ngqo kwiipeptides, izilwa-buhlungu, okanye abathwali

Iimpawu zeMveliso (iQela leGentolex):

Ukucoceka okuphezulu, ukulungele-ukudibanisa i-NHS ester

Ifanelekile kwi-bioconjugation kunye nophando lonikezelo olujoliswe kuyo

I-Ste-γ-Glu-AEEA-AEEA-OSU ilungele uphuhliso lwenkqubo yokuhanjiswa kwechiza oluchanekileyo.