I-Atosiban Acetate Esetyenziselwa Ukuzalwa Kwangaphambi kwexesha
Iinkcukacha zeMveliso
| Igama | Atosiban |
| Inombolo yeCAS | 90779-69-4 |
| Ifomula yemolekyuli | I-C43H67N11O12S2 |
| Ubunzima bemolekyuli | 994.19 |
| Inombolo ye-EINECS | 806-815-5 |
| Indawo yokubilisa | 1469.0±65.0 °C (Kuxelwe kwangaphambili) |
| Ukuxinana | 1.254±0.06 g/cm3(Kuxelwe kwangaphambili) |
| Iimeko zokugcina | -20°C |
| Ukunyibilika | H2O:≤100 mg/mL |
Inkcazo
I-atosiban acetate yi-disulfide-bonded cyclic polypeptide equkethe i-9 amino acids. Yimolekyuli ye-oxytocin elungisiweyo kwizikhundla ze-1, 2, 4 kunye ne-8. I-N-terminus ye-peptide yi-3-mercaptopropionic acid (thiol kunye neqela le-sulfhydryl ye [Cys] 6 yenza ibhondi ye-disulfide), i-C-terminal ikwimo ye-amide, i-amino acid yesibini kwi-D-terminal e-D-terminal) kunye ne-atosiban acetate isetyenziselwa amayeza njengeviniga Ikhona kwimo yetyuwa ye-asidi, eyaziwa ngokuba yi-atosiban acetate.
Isicelo
I-Atosiban i-oxytocin kunye ne-vasopressin ye-V1A edibeneyo ye-receptor antagonist, i-oxytocin receptor ifana nesakhiwo esifana ne-vasopressin V1A receptor. Xa i-oxytocin receptor ivaliwe, i-oxytocin isenokuthi isebenze nge-V1A receptor, ngoko ke kuyimfuneko ukuvala iindlela ezimbini ze-receptor ngexesha elifanayo, kunye ne-antagonism enye ye-receptor enye inokuthintela ngokufanelekileyo ukuchithwa kwe-uterine. Esi sesinye sezizathu eziphambili zokuba kutheni i-β-receptor agonists, i-calcium channel blockers kunye ne-prostaglandin synthase inhibitors ayikwazi ukuthintela ngokufanelekileyo ukuchithwa kwesibeleko.
Isiphumo
I-Atosiban ngumchasi odibeneyo we-receptor we-oxytocin kunye ne-vasopressin V1A, ukwakheka kweekhemikhali kufana nezi zibini, kwaye inobudlelwane obuphezulu be-receptors, kwaye ikhuphisana ne-oxytocin kunye ne-vasopressin ye-V1A receptors, ngaloo ndlela ivimbela indlela yesenzo se-oxytocin kunye ne-vasopressin kunye nokunciphisa ukuchithwa kwesibeleko.
