I-caspoFungan yosulelo lwe-antifungal
Iinkcukacha zemveliso
| Igama | I-CaspoFungun |
| Inombolo ye-CAS | 162808-62-0 |
| Ifomula yemolekyuli | C52h88N10O15 |
| Ubunzima bemolekyuli | I-1093.31 |
| Inombolo ye-einecs | Ngo-1806241-263-5 |
| Indawo yokubila | I-1408.1 ± 65.0 ° C (iqikelelwe) |
| Ukuxinana | 1.36 ± 0.1 g / cm3 (eqikelelweyo) |
| I-acididity ilunge | (pka) 9.86 ± 0.26 (iqikelele) |
Izithethantonye
I-CS-1171; i-caspofungine; i-caspoFungun; i-casporfungun; pneumocandinb0,1 - ((i-4s, (10,12-(i-10,12-Dimyethyl -1 -1--o gootetradecyl) -4-i-hydroxy-l-i-nithine
Iipropathi zeekhemikhali
I-caspoFungin yayiyi-Echinocandin yokuqala evunyiweyo kunyango losulelo oluhlaselweyo. I-VITRO kwaye kwiimvavanyo ze-vivo eziqinisekisile ukuba i-caspoFungun inomsebenzi olungileyo ochasene noPathogens obalulekileyo-icace kunye ne-aspergils. I-CaspoFungin inokuphuphuma udonga lweseli ngokuthintela i-synthesis ye-1,3-β-glucan. Ngokukuko, i-caspofungin inefuthe elihle kunyango lwabantu abahlukeneyo kunye ne-aspergillosis.
Isiphumo
. Emva kolawulo lwe-intravenous, i-Plsma ixilongo ihla ngokukhawuleza ngenxa yokusasazwa kwezicubu, kulandelwa yindawo yokuphinda ithathe ichiza kwichiza. Imetabolism ye-caspofungin inyuke ngedosi eyandayo kwaye yayinxulumene ne-dose ngexesha lokuqina kwemo yokuqina. Ke ngoko, ukufezekisa amanqanaba onyango asebenzayo kwaye uphephe ukuqokelelwa kweziyobisi, idosi yokuqala yokulayisha kufuneka ilawulwe yidosi yesondlo. Xa usebenzisa i-cytochrome p4503a4 I-Insoces ngaxeshanye, njenge-rifampicin, i-carbamazepine, i-dexametine, i-dexametine, i-phengtoin, njl njl, njl. Njl.
Iphawu
Izalathiso ezivunyiweyo ze-FDA ze-caspofyuli zibandakanya: I-Fever nge-Nutropenia: Ichazwe njenge: I-Fever> 38 ° C ngobalo lwe-neutrophil (i-ANC) ≤1000 / ML kwaye ichazwe kwi-500 / ml. Ngokweengcebiso zeZifo zoBuso boShicings . I-2. I-DesasIoindis: I-IDSA icebisa ukuba i-Echinocandins (njenge-caspoFungun) njengechiza elikhethiweyo kwiCandidemia. Ingasetyenziselwa ukunyanga i-Intra-isisu, i-peritonitis kunye nosulelo lwesifuba olubangelwa lusulelo lwe-bandica. I-3. I-EsophagegeAl BandiavageIndial I-Interdatism: I-Caspofungin inokusetyenziselwa ukunyanga abantu baseSophageal kwizigulana ezinempikiswano okanye ekunganyamezelweni kwezinye iindlela. Izifundo ezininzi ziye zafumanisa ukuba isiphumo sonyango lwe-capepofungin sithelekiswa ne-fluconazole. I-4. I-AspergilLosis: I-CaspoFungun ivunyiwe kunyango lwe-AspergilGillosis ehlaselayo kwizigulana ezingenazichiza, ukuchasana nokungasebenzi kweyeza eliphambili, iVolorionatsole. Nangona kunjalo, i-Echinocandin ayikhuthazwa njengonyango lomgca wokuqala.
