I-daptomycin 103060-5-3 kwizifo ezosulelayo
Iinkcukacha zemveliso
| Igama | Daptomycin |
| Inombolo ye-CAS | I-103060-3-33 |
| Ifomula yemolekyuli | C72h101n17o26 |
| Ubunzima bemolekyuli | I-1620.67 |
| Inombolo ye-einecs | I-600-389-2 |
| Indawo yokunyibilika | 202-204 ° C |
| Indawo yokubila | 2078.2 ± 65.0 ° C (iqikelelwe) |
| Ukuxinana | 1.45 ± 0.1 g / cm3 (iqikelele) |
| Indawo yokuflasha | 87 ℃ |
| Iimeko zokugcina | Itywinwe kwi-freezer, engaphantsi kwe-42 ° C |
| Ukunyibilikisa | I-methanol: inyibilikisela / ml |
| I-acididity ilunge | (PKA) 4.00 ± 0.10 (xela kwangaphambili) |
| Ifom | umgubo |
| Umbala | Ayinambala ukuze ityheli |
Izithethantonye
I-N- ← 1 ; N- decanoyl-L-T-D-ASP-L-ASPL-L-L-I-L-GY-M-GLY-D-GY-R-S-L-I-AMP-GLYZO-]; N- I-ECELL) -L-tryptophyl-D-Asparaginyl-Lα-LαParyGlyb-Lα-Alanyl-Lα-Alarl-Alaml-(3r) -3-α- I-Glutamyl-α, i-2-diamino-γ-i-ogo-benza; dapcin; dapcin; dapcin; i-dapcin; i-dapcin; i-daptomycin (i-daptomycin (Ly14603)
Inkcazo
I-antibiotic daptomycin yi-cyclic libibiottic ye-antibiogycys ye-bacterialcycan ye-bacterialcan ngokuphazamisa izithuthi ze-Amino Acid kwi-Aminone. Ukutshintsha iipropathi ze-cytoplasmic membrane kunokuphazamisa umsebenzi we-wicrane ye-wicrane ngeendlela ezininzi kwaye ubulala ngokukhawuleza intsholongwane. Ukongeza kubuchule bayo bokwenza into kwi-GACTEAIA efanelekileyo ye-GRAM, i-dapatomycin ibaluleke ngakumbi kwimingxunya ye-ofisi emiselweyo yokunganyangeki eMeticillin, i-vanfolcin, kunye ne-nquitzolid evitro. Inomsebenzi onamandla, kwaye le ndawo ineempembelelo ezibaluleke kakhulu kwezosulelo kwizigulana ezosulela kakhulu. I-Eosinophilic Pneumonia sisifo esinqabileyo nesiziintloko ngeempawu kubandakanya umkhuhlane, ukukhohlela, ukuphefumla, kunye nobunzima bokuphefumla.
Isiphumo se-Antibacterrial
I-daptomycin inomsebenzi olungileyo webactetiostatic ngokuchasene ne-bacteria engaqhelekanga yentsholongwane, enjenge-MIC = 0.06-0.5 μ5 μg / ml ye-meticillin-padlococcus Aures (i-MRSA). Mic = 0.0625 ~ 1μg / ml ye-bacteria, mic = 0.1μ ~ 0.5μg / mic = 2.5μ00 i-enterococcus, i-mic = 2.5μ00 ye-gerococcus yiyo 0.5 ~ 1μg / Ml, kunye noMIki we-Enterococcus enganyangekiyo kwi-GlycopePikide i-gelycootics yi-1 ~ 0μg / ml.
