I-Terlippressin i-ecetate ye-esophageal vir
Iinkcukacha zemveliso
| Igama | N |
| Inombolo ye-CAS | I-14636-12-5 |
| Ifomula yemolekyuli | C52h74n16O15s2 |
| Ubunzima bemolekyuli | 1227.37 |
| Inombolo ye-einecs | 238-680-8 |
| Indawo yokubila | Ngo-1824.0 ± 65.0 ° C (iqikelelwe) |
| Ukuxinana | 1.46 ± 0.1 g / cm3 (iqikelele) |
| Iimeko zokugcina | Gcina indawo emnyama, i-InErt Sollre, Ivenkile kwi-freezer, engaphantsi kwe-15 ° C. |
| I-acididity ilunge | (pka) 9.90 ± 0.15 (iqikelele) |
Izithethantonye
[N-α-ictriglylyl-8-lysine] -Uskopin; 130: Pn: Won: Won: wh: I-1-triglylylyl-8-lysinevapresn; I-Nly-gelycyl-vlycyl-gilycyl- [8-lysine] -askopin; I-Nly-gelycyl-vlycyl-vlycyl-lysine-viskopin; I-Nly-gelycylglyglyglyglyg -cprestin; I-Ny-Gly-Gly-Gly-8-lys-vis-vaskopin; I-Terlisipresn, i-terlipicrerine, terlippressina, terlippressnum.
Inkcazo
I-Terlippressin, igama lekhemikhali le-triglylycysine vaspressin, lilungiselelo elitsha le-vastering vasteresn elisebenza. Luhlobo lwe-prodrug, engasebenzi ngokwayo. Isebenza nge-aminopeptidase kwi-vivo ukuba ikhuphe kancinci "ukukhupha" i-lysine vaskoptoloss esebenzayo emva kokususa iintsalela ezintathu ze-glyctus kwi-N-themisos. Ke ngoko, i-Terlipicin isebenza njengendawo yokugcina ikhupha i-lysine vaskopreskon kwinqanaba eliqinileyo.
Isiphumo se-terlippressin kukufumana isivumelwano se-vascular spicture vascle esigudileyo kwaye sinciphise ukuhamba kwegazi (njengokunciphisa ukuhamba kwegazi ebusweni begazi ,. Kwelinye icala, inokunciphisa iPlasma ifuthe le-Reanin uxinzelelo, ngaloo ndlela kunyusa ukuhamba kwegazi, kuphucula umsebenzi we-renal kunye nokwandisa imveliso yezigulana kwizigulana ezine-hepatoreal syndrome. I-Terlippresn okwangoku kuphela kwechiza elinokuphucula inqanaba lesigulana esine-esophagegeal upemorrhage. Yayisetyenziswa ikakhulu kunyango lweklinikhi lwe-viricerrhage. Ukongeza, i-terlippressin iphinde isetyenziswe ngempumelelo kwisibindi kunye ne-fitney. Ngokubanzi, kunokwenzeka ukuba udlale indima eluncedo kwi-avictory yoyikiso kunye nokuhlaziywa kwentliziyo. Xa kuthelekiswa ne-vasopressin, inesiphumo esihlala ixesha elide, ingenzi iingxaki eziyingozi, kubandakanya neengxaki ze-fibrinolysis kunye neengxaki ezinkulu kwi-Cardiovascular System, kwaye ilula ukuyisebenzisa (ebaluleke kakhulu ekubambeni nasekukhathalelo. Ukuhlangula kunye nonyango lwezigulana ezigula kakhulu.
