Terlipressin Acetate for Esophageal Variceal ukopha
Iinkcukacha zeMveliso
| Igama | N-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin |
| Inombolo yeCAS | 14636-12-5 |
| Ifomula yemolekyuli | I-C52H74N16O15S2 |
| Ubunzima bemolekyuli | 1227.37 |
| Inombolo ye-EINECS | 238-680-8 |
| Indawo yokubilisa | 1824.0±65.0 °C (Kuxelwe kwangaphambili) |
| Ukuxinana | 1.46±0.1 g/cm3(Kuxelwe kwangaphambili) |
| Iimeko zokugcina | Gcina kwindawo emnyama, umoya opholileyo, Gcina kwisikhenkcisi, ngaphantsi kwe-15°C. |
| I-acidity coefficient | (pKa) 9.90±0.15 (Kuxelwe kwangaphambili) |
Izithethantonye
[N-α-Triglycyl-8-lysine] -vasopressin;130:PN: WO2010033207SEQID:171claiMedprotein; 1-Triglycyl-8-lysineVasopressin; Nα-Glycyl-glycyl-glycyl-[8-lysine] -vasopressin; Nα-Glycyl-glycyl-glycyl-lysine-vasopressin; Nα-Glycylglycylglycyl-vasopressin; Nα-Gly-Gly-Gly-8-Lys-vasopressin; I-Terlipressin, i-Terlipressine, i-Terlipressina, i-Terlipressinum.
Inkcazo
I-Terlipressin, enegama lekhemikhali yi-triglycyllysine vasopressin, yinto entsha yokwenziwa kwe-vasopressin esebenza ixesha elide. Luhlobo lweprodrug, engasebenziyo ngokwayo. Yenziwa yi-aminopeptidase kwi-vivo ukuze "ikhulule" i-lysine vasopressin esebenzayo emva kokususa iintsalela ze-glycyl ezintathu kwi-N-terminus yayo. Ke ngoko, i-terlipressin isebenza njengendawo yokugcina amanzi ekhupha i-lysine vasopressin ngesantya esizinzileyo.
Impembelelo ye-pharmacological ye-terlipressin kukukontraka kwe-splanchnic vascular smooth muscle kunye nokunciphisa ukuhamba kwegazi kwe-splanchnic (njengokunciphisa ukuhamba kwegazi kwi-mesentery, i-spleen, i-uterus, njl.), ngaloo ndlela ukunciphisa ukuhamba kwegazi kwi-portal kunye noxinzelelo lwe-portal. Ngakolunye uhlangothi, kunokunciphisa i-plasma Umphumo wokugxilwa kwe-renin, ngaloo ndlela ukwandisa ukuhamba kwegazi kwezintso, ukuphucula umsebenzi wezintso kunye nokwandisa ukukhutshwa komchamo kwizigulane ezine-hepatorenal syndrome. I-Terlipressin ngoku kuphela kwechiza elinokuphucula izinga lokusinda kwezigulana ezine-esophageal variceal hemorrhage. Yayisetyenziswa kakhulu kunyango lweklinikhi ye-variceal hemorrhage. Ukongeza, i-terlipressin isetyenziswe ngempumelelo kwisibindi kunye nezintso. Ngokubanzi, kunokwenzeka ukuba idlale indima enenzuzo ekuhlaliseni ukothuka kwe-refractory kunye nokuvuselelwa kwe-cardiopulmonary. Xa kuthelekiswa ne-vasopressin, inefuthe elihlala ixesha elide, ayibangeli iingxaki ezinobungozi, kuquka i-fibrinolysis kunye neengxaki ezinzulu kwi-cardiovascular system, kwaye kulula ukuyisebenzisa (isitofu se-intravenous), efanelekileyo ngakumbi kukhathalelo olubukhali kunye nolubalulekileyo. Ukuhlangula kunye nonyango lwezigulane ezigula kakhulu.
