I-Carbetocin ukuthintela ukungaphumeleli kwe-iTrine kunye ne-PostParrul Hemorrhage
Iinkcukacha zemveliso
| Igama | ICarbetocin |
| Inombolo ye-CAS | 37025-55-1 |
| Ifomula yemolekyuli | C45h69N12O12s |
| Ubunzima bemolekyuli | 988.17 |
| Inombolo ye-einecs | 253-312-6-6 |
| Ukujikeleza okuthile | D -69.0 ° (C = 0.25 kwi-1m acetic acid) |
| Indawo yokubila | I-1477.9 ± 65.0 ° C (iqikelelwe) |
| Ukuxinana | 1.218 ± 0.06 g / cm3 (eqikelelweyo) |
| Iimeko zokugcina | -15 ° C |
| Ifom | umgubo |
Izithethantonye
I-butyryl-tyr (mna) -ile-gln-pro-leu-leu-gly-nh2, (isulfiidebondetbetryl-4-Ylandcys); I-butyryl-tyr (mna) -ile-gln-i-cyn-pro-leu-gly-th2triflum; (I-butyryl1, tyr (mna) 2) -1-I-Carbaoxytoc Intrizioceracetalt; (I-byyryl1, tyr (mna) 2) -oxytocin; (I-byyryl1, tyr (mna) 2) -Ioxytociintrizinglumuoceracetalt; ICarbetocin; ICarbetocintrizinglumuOceracetalt; (2-o-methyltyrosine) -De-Amino-1-Carbaoxtocin
Umsebenzi webhayiloji
I-Carbetocin, i-oxytocin (OT) i-analog, i-oxytocin ye-Agonist nge-7.1 nm. I-Carbetocin inamachaphaza aphezulu (ki = 1.17 μm) ye-chimeric n-themisor ye-Oxytocin Caceptor. I-Carbetocin inokubakho kuPhepha loPhezulu lwe-Pomorrim. I-Carbetocin inokungena kwigazi legazi kwaye inomsebenzi-njengokusebenza ngokusebenzisa i-Oxytocin ReadPritors kwi-CNS.
Umsebenzi
I-Carbetocin yi-oxty ye-oxytocin ene-oxytocin 8-peptide nge-Agodinies, kwaye iipropathi zayo zekliniki kunye ne-phammacological ziyafana ne-Oskocin yendalo. Njengayi-Oxetocin, iCarbetocin Bindstors kwi-hormone ye-hormone ye-iTrine Sheet, ebangela isingqisho se-hertic scous, esonyusa ithowuni yalo kunye nokwanda kwe-therine ye-therine. Amanqanaba e-Oxytocin amanqanaba e-Utoris asezantsi kwindawo engakhulelwa, enyuka ngexesha lokukhulelwa, kunye nencopho ngexesha lokusebenza. Ke ngoko, iCarbetocin ayinampembelelo kwi-uterus engakhulelwanga, kodwa inefuthe lekhontrakthi enamandla kwi-uterus ekhulelweyo kunye nesibeleko esandula ukuveliswa.
Guqula ulawulo
Utshintsho lulawulwa ngokwenkqubo. Ngokusekwe kwifuthe kunye nomngcipheko kunye nobungozi, utshintsho luhlewe njengeyona nto iphambili, ebuncinci nezendawo. Utshintsho lwesiza lunefuthe elincinci lokhuseleko kunye nomgangatho wemveliso, kwaye ke awudingi imvume kunye nesaziso kuMthengi; Utshintsho oluncinci lunefuthe elilinganayo lokhuseleko kunye nomgangatho wemveliso, kwaye kufuneka kwazise uMthengi; Utshintsho olukhulu lunefuthe eliphezulu khuseleko kunye nomgangatho wemveliso, kwaye ufuna ukuvunywa nguMthengi.
Ngokwenkqubo, ulawulo lokutshintsha luqalwa ngokutshintsha kwesicelo apho iinkcukacha zotshintsho zichaziwe. Uvavanyo lwenziwe emva kwesicelo, elenziwayo ngolawulo lotshintsho lwamasebe afanelekileyo. Okwangoku, ulawulo lotshintsho luhlelwa kwinqanaba eliphambili, inqanaba ngokubanzi kunye nenqanaba elincinci. Emva kovavanyo olufanelekileyo kunye nokuhlelwa, lonke ulawulo lwenqanaba lokutshintsha kufuneka luvunywe nguMphathi we-QA. Ulawulo lotshintsho lwenziwa emva kokuvunywa ngokwesicwangciso sokusebenza. Ulawulo lotshintsho luvaliwe ekugqibeleni emva kokuba i-QA iqinisekisa ukuba ulawulo lotshintsho luphunyezwe ngokufanelekileyo. Ukuba kubandakanya isaziso somthengi, umthengi kufuneka aziswe ngexesha emva kokuba ulawulo lokutshintsha oluvunyiweyo
