I-Linaclotide ye-Gastrointestinal Disorders 851199-59-2
Iinkcukacha zeMveliso
| Igama | I-Linaclotide |
| Inombolo yeCAS | 851199-59-2 |
| Ifomula yemolekyuli | I-C59H79N15O21S6 |
| Ubunzima bemolekyuli | 1526.74 |
Izithethantonye
ILinacllotide;Linaclotide;LinaelotideAcetate;Linaelotide;CY-14;Liclotide;Argpessin;L-Tyrosine,L-cysteinyl-L-cysteinyl-L-α-glutamyl-L-tyrosyl -L-cysteineyl-L-cysteineyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteineyl-L-threonylglycyl-L-cysteineyl-,cyclic(1→6),(2→10),(5→13)-tris(disulfide)
Inkcazo
I-Linaclotide, i-synthetic peptide structure equkethe i-14 amino acids, inxulumene nentsapho engapheliyo ye-guanosine peptide kwaye iyona kuphela i-GC-C (guanylate) evunyiweyo ye-GC-C (guanylate) i-Cyclase-C) iziyobisi ze-agonist ezivunyiweyo kunyango lwe-bowel syndrome enomsindo kunye ne-constipation (IBS-C) kunye nabantu abadala abangapheliyo (i-CICIC) kwi-constipation idiopathic.
Iipropati zeMichiza
I-Linaclotide ngumgubo omhlophe omhlophe we-amorphous; Inyibilika kancinane emanzini kunye nesisombululo se-sodium chloride emanzi (0.9%).
Ingaba isebenza kanjani
I-Linaclotide yi-guanylate cyclase-C receptor agonist (GCCA) ene-visceral analgesic kunye nomsebenzi we-endocrine. Bobabini i-linaclotide kunye ne-metabolite yayo esebenzayo inokubophelela kwi-guanylate cyclase-C (GC-C) i-receptor kwi-luminal surface ye-epithelium yamathumbu amancinci. Kwiimodeli zezilwanyana, i-linaclotide inciphisa intlungu ye-visceral kwaye inyuse ukuhamba kwesisu ngokusebenza kwe-GC-C, kwaye ebantwini, ichiza likwanyusa i-colonic transit. Isiphumo sokusebenza kwe-GC-C kwandiswe kwi-intracellular kunye ne-extracellular cGMP (i-cyclic guanosine monophosphate) yoxinaniso. I-cGMP ye-Extracellular inokunciphisa umsebenzi we-nerve fibers kunye nokunciphisa intlungu ye-visceral kwizilwanyana zemodeli. I-Intracellular cGMP inokunyusa i-secretion ye-chloride kunye ne-bicarbonate emathunjini amancinci ngokuvula i-CFTR (i-cystic fibrosis transmembrane conductance regulator), ekugqibeleni ikhokelela ekunyuseni kwe-intestinal secretion encinci kunye nesantya sokuhamba kwamathumbu amancinci.
FAQ
Ngaba uqinisekisa ukuhanjiswa okukhuselekileyo nokukhuselekileyo kweemveliso?
Ewe, sihlala sisebenzisa umgangatho ophezulu wokupakisha ngaphandle. Sikwasebenzisa ukupakishwa kweengozi ezikhethekileyo kwimpahla enobungozi kunye nabathumeli abaqinisekisiweyo abagcina izinto ezibandayo kwizinto ezinobushushu bobushushu. Ukupakishwa kweengcali kunye neemfuno zokupakisha ezingekho mgangathweni zingafaka intlawulo eyongezelelweyo.
Kuthekani ngeemali zokuthumela ngenqanawa?
Iindleko zokuthumela ngenqanawa zixhomekeke kwindlela okhetha ngayo ukufumana iimpahla. I-Express yeyona ndlela ikhawulezayo kodwa ikwabiza kakhulu. Ngokuthuthwa elwandle sesona sisombululo sisixa esikhulu. Ngokuchanekileyo amaxabiso omthwalo sinokukunika kuphela ukuba siyazazi iinkcukacha zesixa, ubunzima kunye nendlela. Nceda uqhagamshelane nathi ngolwazi oluthe vetshe.
